Chronic Stress Induced Remodeling of the Prefrontal Cortex and Its Impact on Decision Making

Author: Khirstyn-Lien Neuroscience and Cognitive Science Date: August 2025 Abstract Chronic stress induces profound structural, functional, and molecular alterations in the prefrontal cortex (PFC), a brain region essential for executive control, working memory, and goal directed decision making. Prolonged exposure to stress hormones and neuromodulators disrupts dendritic architecture, reduces synaptic connectivity, and alters neurotransmission, shifting … More Chronic Stress Induced Remodeling of the Prefrontal Cortex and Its Impact on Decision Making